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为探讨内皮素、前列腺素同动脉粥样硬化闭塞症(PASO)的关系,我们对50例PASO患者进行血浆ET、血栓素B_2(TXB_2)、6酮-前列腺素F_(1α)(6-K-PGF_(1α))测定,现将结果分析报道如下。 材料和方法 一、一般资料:50例(男39,女11),PASO住院病人,年龄61～87岁,平均68岁。另选择30例本院健康献血员,作为正常对照组。 二、治疗方法:静脉应用PGE_1,低分子右旋糖酐,维脑路通,肌肉注射罂粟碱,配合活血化淤中医中药。对具有手术指征者,采用转流术或截肢手术。 三、临床分期及疗效标准:均采用中西医结合学会周围血管疾病专业委员会制定的分期疗效标准。PASO采用三期三级分类法:Ⅰ～Ⅲ期分别为缺血期、营养障碍期及坏疽期,Ⅲ期病人据坏疽程度分为三级。疗效标准分为临床治愈(29例),显著有效(9例),进步(8例)和无效(4例)。
To investigate the relationship between endothelin, prostaglandin and atherosclerosis obliterans (PASO), 50 patients with PASO were enrolled in this study. Plasma endothelin, thromboxane B 2 (TXB 2), 6 keto-prostaglandin F 1alpha (6-K -PGF_ (1α)) determination, the results of the analysis are reported below. Materials and methods First, the general information: 50 cases (39 men and 11 women), PASO hospitalized patients, aged 61 to 87 years, mean 68 years. Another 30 healthy blood donors were selected as normal control group. Second, the treatment: intravenous application of PGE_1, low molecular weight dextran, Venoruton, intramuscular injection of papaverine, with traditional Chinese medicine promoting blood circulation. For those with surgical indications, the use of shunt or amputation surgery. Third, clinical staging and efficacy standards: are using the Society for Integrative Medicine peripheral vascular disease developed by the Committee of staging standards. PASO using three stages of three categories: Ⅰ ~ Ⅲ were ischemic period, nutritional disorders and gangrene, Ⅲ patients according to the degree of gangrene is divided into three levels. Efficacy standards are divided into clinical cure (29 cases), significantly effective (9 cases), progress (8 cases) and ineffective (4 cases).