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近年来,国内外一些文献报导,在一些获得性疾病而并不存在地中海贫血的患者有正常的血红蛋白A_2或HbF比率改变,少数出现HbH,这有可能造成误诊。但亦有希望通过此种获得性血红蛋白异常的研究进一步了解血红蛋白合成及调节的机制,这对于探索血红蛋白病的治疗和进一步了解某些疾病继发血红蛋白异常的规律性较有意义。例如当某些疾病缓解时,此种继发性的血红蛋白异常亦消失,这有助于对病情及预后判断。为了探索HbH、HbA_2及HbF在某些血液病的诊断意义。我院近2年对各种类型的白血病、血液系统肿瘤、再生障碍性贫血(再障)、阵发性睡眠性血红蛋白尿(PNH)等共98例进行治疗前的血红蛋白电泳检查,并分析其临床意义。
In recent years, some domestic and foreign literatures reported that in some patients with acquired diseases who do not have thalassemia, there is a change in the normal ratio of hemoglobin A_2 or HbF and a few cases of HbH, which may cause misdiagnosis. However, it is also hoped that this understanding of acquired hemoglobin abnormalities can further understand the mechanism of hemoglobin synthesis and regulation, which is of great significance for exploring the treatment of hemoglobinopathies and further understanding the regularity of secondary hemoglobin abnormalities in some diseases. For example, when certain diseases are alleviated, such secondary hemoglobin abnormalities also disappear, which helps to judge the condition and prognosis. In order to explore the diagnostic significance of HbH, HbA_2 and HbF in some blood diseases. In the past two years, our hospital examined 98 cases of various types of leukemia, hematologic malignancies, aplastic anemia (aplastic anemia) and paroxysmal nocturnal hemoglobinuria (PNH) in the past two years and analyzed the hemoglobin electrophoresis Clinical significance.