自 Petty 等首次提出“成人呼吸困难综合征”(ARDS)以来已快20年了。他描述的呼吸衰竭有多种互不相关的病因,且多数并非对肺的直接侵袭。它的表现通常为呼吸困难,即使提高吸入 O_2浓度也难纠正低氧血症。胸片显示弥散性浸润,常提示已有肺水肿。虽然首次报告 ARDS 时已作了大量基础和临床研究,但确切机制尚未完全阐明。首 It has been almost 20 years since Petty et al first proposed “adult respiratory distress syndrome” (ARDS). He described a number of unrelated causes of respiratory failure and most were not directly affected by the lungs. Its performance is usually dyspnea, even if the increase in inhaled O2 concentration is also difficult to correct hypoxemia. Chest radiograph showed diffuse infiltration, often prompted pulmonary edema. Although a large number of basic and clinical studies have been made when ARDS was first reported, the exact mechanism has not been fully elucidated. first