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在１９３例急性分离大鼠皮层神经元内面向外式记录膜片上，记录到２例能为ＡＴＰ和优降糖所阻断的含有亚电导的通道电流。其电流幅度分布直方图符合高斯分布，并能很好地进行二级拟合；主电导水平分别为１９１．８ｐＳ和１９４．５ｐＳ，亚电导水平分别为１５３．２ｐＳ和１１６.１ｐＳ；亚电导成份分别占单位事件总数的３５．０５％和２９.８４％；通道活动呈高电流水平与低电流水平交替开放状态，没有高低电流叠合现象。这些结果表明这种Ｋ_ＡＴＰ通道的多电导开放电流不是两个或多个独立通道的开放所致，而是同一通道的不同亚型状态交互活动（即高电导和低电导状态相互转换）的表现。从而提示神经细胞膜上的Ｋ_ＡＴＰ通道可能受某种或某些膜内外环境的变化影响导致其构象改变，从而引发多种亚型交替活动现象。
In 193 cases of acutely isolated rat cortical neurons inside out facing recording membrane, 2 cases were recorded with sub-conductance-containing channel currents blocked by ATP and glyburide. The current amplitude distribution histogram is Gaussian distribution and can be well fitted for second order. The main conductance levels are 191.8pS and 194.5pS respectively, and the subconductivity levels are 153.2pS and 116.1pS respectively. Accounting for 35.05% and 29.84% of the total number of unit events respectively. The channel activities showed alternating high and low current levels with no overlap of high and low current. These results indicate that the multi-conductance open current of this K_ATP channel is not caused by the opening of two or more independent channels but rather the performance of the interaction of different subtypes of the same channel (ie the conversion of high conductivity and low conductivity). Suggesting that the K_ATP channel on the membrane of neurons may be affected by some or some of the changes in the membrane inside and outside the environment resulting in conformational changes, which led to a variety of subtypes alternating activity.