对采自新疆地区维吾尔族自然人群、职业献血员、肝硬化、肝细胞癌患者血清分别进行了抗－ＨＣＶＥＬＩＳＡ和ＨＣＶＲＮＡ基因型检测。结果显示：该地区自然人群、职业献血员、肝硬化、肝细胞癌患者抗－ＨＣＶ阳性率分别为２．０％、３５．７％、４２．５％、２０．８％，ＨＣＶ感染者中多数具有输血及献血史，职业献血员、肝硬化和肝细胞癌患者ＨＣＶ感染比例较高。该人群ＨＣＶ基因型以混合型感染（占４９．７％）为主，单一基因型感染以Ⅱ型（占２６．２％）为主，提示当地可能存在严重的不同基因型ＨＣＶ的混合感染。 Anti-HCV VISA and HCV RNA genotypes were detected in sera from patients with Uygur nationality, professional blood donors, cirrhosis and hepatocellular carcinoma collected from Xinjiang Autonomous Region. The results showed that the positive rates of anti-HCV in the natural population, professional blood donors, cirrhosis and hepatocellular carcinoma patients in this area were 2.0%, 35.7%, 42.5% and 20.8%, respectively Most have a history of blood transfusion and blood donation, occupational blood donors, cirrhosis and hepatocellular carcinoma in patients with a higher proportion of HCV infection. The prevalence of HCV genotypes in this population was 49.7%. The single genotype was predominantly type Ⅱ (26.2%), suggesting that there might be severe mixed HCV infection in different genotypes.