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自１９７８年血浆制备的乙肝疫苗问世以来，乙肝的预防己取得了可喜的成绩。已有大量的研究显示，无论是血源性还是基因工程乙肝疫苗，其免疫保护作用都是肯定的［１］。然而在人群推广乙肝疫苗接种中存在有免疫不应答问题，这方面的研究虽有报道，但缺乏规范的免疫应答检测标
Prevention of hepatitis B has yielded encouraging results since the advent of plasma-derived hepatitis B vaccine in 1978. A large number of studies have shown that both the blood-borne and the genetically engineered hepatitis B vaccines have certain immunoprotective effects [1]. However, there are immunological non-response problems in the popularization of hepatitis B vaccination in population. Although studies in this area have been reported, there is a lack of normative immune response test