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目的 :探讨狼疮性肾炎 (LN)患者血清中IL 18和sFas/sFasL变化及相关性。方法 :利用夹心 ELISA方法检测 35例LN患者和 18例正常健康人群血清中IL 18,sFas和sFasL水平。结果 :IL 18水平比较 ,LN组和活动期LN组显著高于静止期LN组及正常对照组 (P <0 0 1) ,而静止期LN患者与正常对照组差异无显著性 (P >0 0 5 )。sFas水平 ,各LN患者组均明显高于正常对照组 (P <0 0 1)。其中LN组血清sFas较非LN组显著增高 (P <0 0 1)。sFasL水平在LN患者组和活动期LN患者与正常对照组差异有显著性 (P <0 0 5 )。而其它各组间差异无显著意义 (P >0 0 5 )。在LN患者组和活动期LN患者血清中IL 18水平与sFas蛋白呈正相关 (P <0 0 1)。结论 :IL 18和sFas/sFasL在狼疮性肾炎患者血清中升高 ,IL 18和sFas水平具有一定相关性 ,提示可能参与LN发病
Objective: To investigate the changes of IL 18 and sFas / sFasL in serum of patients with lupus nephritis (LN) and their correlation. Methods: Serum levels of IL 18, sFas and sFasL in 35 patients with LN and 18 healthy controls were detected by sandwich ELISA. Results: The levels of IL-18 in LN group and active LN group were significantly higher than those in LN group and normal control group (P <0.01), while there was no significant difference between LN group and control group (P> 0) 0 5). sFas levels in LN patients were significantly higher than the normal control group (P <0.01). Serum sFas in LN group was significantly higher than that in non-LN group (P <0.01). The level of sFasL in LN patients and active LN patients was significantly different from that in controls (P <0.05). There was no significant difference among other groups (P> 0.05). The level of IL-18 in serum of patients with LN and active LN was positively correlated with sFas (P <0.01). Conclusion: IL 18 and sFas / sFasL are elevated in the serum of patients with lupus nephritis, IL 18 and sFas levels have a certain correlation, suggesting that may be involved in the pathogenesis of LN