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随着消化道激素研究的深入,许多作者认为某些消化道激素对胰腺具有保护作用,并将其用于实验性急性胰腺炎和急性胰腺炎病人的治疗。一、胰高血糖素在消化道激素对胰腺的保护作用中,胰高血糖素是较早研究的一种激素。因其能抑制正常人的胰腺外分泌,早在1971年,Knight等就试用胰高血糖素治疗急性胰腺炎,取得一定的疗效。胰高血糖素能有效地降低急性胰腺炎患者的血清淀粉酶,缩短病人疼痛持续的时间。Manabe等用缺乏胆碱的饲料和乙硫氨酸饲养小鼠,造成小鼠的急性胰腺炎。认为胰高血糖素不仅能使小鼠实验性急
With the deepening of research on gastrointestinal hormones, many authors believe that certain gastrointestinal hormones have a protective effect on the pancreas and are used in the treatment of patients with experimental acute pancreatitis and acute pancreatitis. First, glucagon In the protective effect of gastrointestinal hormones on the pancreas, glucagon is an early study of a hormone. Because of its ability to inhibit normal pancreatic exocrine, as early as 1971, Knight and other trials of glucagon treatment of acute pancreatitis, and achieved a certain effect. Glucagon can effectively reduce the serum amylase in patients with acute pancreatitis, shorten the duration of the patient’s pain. Manabe et al. Fed mice with choline-deficient diet and ethionine, causing acute pancreatitis in mice. It is believed that glucagon not only renders mice experimental acute