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目的探讨血浆血小板激活因子乙酰水解酶pPAF-AH基因G994T突变与中国人群脑出血发病的相关关系。方法利用等位基因特异性聚合酶链反应技术分析了150例原发性脑出血病人和150例非脑血管病对照组pPAF-AH基因的基因型位点频率。结果T等位基因在脑出血组的频率是3%,在对照组是4%,GT杂合子在脑出血组和对照组频率分别为6.8%和8.5%,两组差异无显著意义。没有发现突变型的纯合子。结论pPAF-AH基因G994T突变与中国人群的脑出血没有明显的相关关系。
Objective To investigate the relationship between the plasma platelet activating factor acetylhydrolase p99A gene mutation and the incidence of cerebral hemorrhage in Chinese population. Methods The allele-specific polymerase chain reaction (PCR) technique was used to analyze the genotype frequency of pPAF-AH gene in 150 patients with primary cerebral hemorrhage and 150 non-cerebrovascular disease controls. Results The frequency of T allele was 3% in cerebral hemorrhage group and 4% in control group. The frequencies of GT heterozygote in ICH group and control group were 6.8% and 8.5%, respectively. There was no significant difference between the two groups. No mutant homozygotes were found. Conclusion The G994T mutation of pPAF-AH gene has no significant correlation with cerebral hemorrhage in Chinese population.