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一项多中心双盲随机试验,对比检查大剂量(1,000mg,每天1次,连续10天)和标准剂量(100mg,每日1次,连续10天)的甲基强的松龙治疗330例急性脊髓损伤病人的疗效。临床试验的结果表明两组病人于急性脊髓损伤后6周和6个月时神经功能(包括运动功能、针刺感、轻触觉)的恢复情况几乎相同。推测应用标准剂量的甲基强的松龙已能改善神经功能,而增加10倍的剂量并不能使疗效更显著。同时,急性脊髓损伤病人应用大剂量甲基强的松龙(1.0g/d持续10天),增加了伤口感染的危险,且可能增加死亡。两组死亡率的差别没有统计学上的意义,但病人在受伤后应用皮质激素的头14天内,大剂
A multicenter, double-blind, randomized trial comparing 330 patients treated with methylprednisolone in large doses (1,000 mg once daily for 10 consecutive days) and standard doses (100 mg daily for 10 consecutive days) Acute spinal cord injury in patients. The results of the clinical trial showed that the recovery of neurological function (including motor function, acupuncture, light touch) was almost identical between the two groups at 6 and 6 months after acute SCI. Speculative use of standard doses of methylprednisolone has been able to improve neurological function, and a 10-fold increase in dose does not make the effect more significant. In the meantime, high-dose methylprednisolone (1.0 g / d for 10 days) is administered to patients with acute spinal cord injury, increasing the risk of wound infection and increasing the risk of death. The difference in mortality between the two groups was not statistically significant, but patients in the first 14 days after the application of corticosteroids, large doses