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继近两年先后在H5N1,H7N9和H10N8亚型禽流感病毒跨种间传播机制研究上取得重大进展后[1~5],中国科学院微生物研究所高福院士领导的研究团队在H6N1亚型禽流感病毒感染人的分子机制上取得新的突破,该研究于2015年5月4日以“Adaptation of avian influenza A(H6N1)virus from avian to human receptor-binding preference”为题在线发表在杂志EMBO J上[3].2013年6月,在台湾发现了全球首例人类感染H6N1亚型禽流感病例.从患者体内所分离的病毒基因序列显示,此病毒为一典型的低致病性禽流感病毒,与台湾本土家禽中的H6N1病毒株非常接近,其跨物种传播的分子机制成为世界科学家所关注的焦点.1972年以来,H6N1亚型禽流
Following the recent two years in the H5N1, H7N9 and H10N8 subtype of bird flu virus cross-species transmission mechanism has made significant progress [1 ~ 5], Institute of Microbiology, Chinese Academy of Sciences led by academician Gao Fu research team in H6N1 subtype of poultry New breakthroughs were made in the molecular mechanism of influenza virus infection in humans published online in the journal “Adaptation of avian influenza A (H6N1) virus from avian to human receptor-binding preference” on May 4, 2015 EMBO J. [3] The world’s first human case of H5N1 subtype avian influenza was found in Taiwan in June 2013. The sequence of the virus gene isolated from the patient shows that the virus is a typical low pathogenic bird The influenza virus, which is very close to the H6N1 strain in Taiwan’s domestic fowl, has become the focus of world scientists for its molecular mechanism of cross-species spread. Since 1972, H6N1 subtype bird flu