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自1961年Schlipk■ter等报导PVNO(聚乙烯吡啶氮氧化物)对实验性矽肺的抑制作用后,很多工作都证明,PVNO治疗能分解实验性矽肺已生成的胶元。已知羟脯氨酸在胶元中含量为12%,因此可测定
Since Schlipkat ter et al. (1961) reported the inhibitory effect of PVNO (polyvinylpyridine nitrogen oxide) on experimental silicosis, a lot of work has proved that PVNO treatment can decompose the generated collagen in experimental silicosis. Hydroxyproline is known to be present in gum cells at a content of 12% and is therefore determinable