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肝内胆汁郁积(简称肝内胆郁)是因胆汁排泌器官功能失调,使胆流障碍所致的综合征。肝细胞内的胆汁排泌器官,是由毛细胆管、内网器(Golgi体)和溶酶体组成。胆红素从肝血窦壁的微突处被摄入肝细胞内,经微粒体的醛糖酸转移酶作用和醛糖酸相结合,变成水溶性物质,然后经溶酶体和内网器排泌入毛细胆管,再经细胆管、叶间小胆管及中隔胆管进入左右肝胆管,最后从胆总管进入十二指肠。分类和病因一、急性肝内胆郁有胆郁型病毒性肝炎,药源性肝病,手术后肝内胆郁,妊娠胆郁,感染伴肝内胆郁。
Intrahepatic cholestasis (referred to as intrahepatic cholestasis) is due to bile excretion organ dysfunction, so that biliary flow caused by the syndrome. Bile excretion organs within the liver cells, is composed of the bile duct, the internal network (Golgi body) and lysosomes. Bilirubin from the liver and sinusoidal wall of the micro-sudden intake of liver cells, the aldonic acid aldolase function and the combination of aldaric acid into water-soluble substances, and then by the lysosome and the network Excretion into the capillary bile duct, and then through the bile duct, small bile duct and septum bile duct into the liver and bile duct, and finally into the duodenum from the common bile duct. Classification and causes First, the acute intrahepatic bile have gallbladder type viral hepatitis, drug-induced liver disease, intrahepatic bile ducts after surgery, pregnancy bile, infection with intrahepatic bile depression.