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为了寻找具有青藤碱类似骨架结构的抗炎活性分子和先导化合物,研究了微生物催化青藤碱和芳基小分子的碳碳交叉偶联反应,发现邻苯二胺、青藤碱与半伏小薄孔(Antrodiella semisupina)的混合培养体系中,邻苯二胺能诱导青藤碱转化成一种结构新颖的代谢物,经NMR和EI-MS鉴定结构为青藤碱N-氧化物(4).首次报道微生物转化青藤碱为青藤碱N-氧化物(4),为发现新的抗炎分子和先导化合物提供了参考.
In order to find anti-inflammatory active molecules and lead compounds with sinoxin-like framework structure, the carbon-carbon cross-coupling reaction of sinomenine and aryl small molecules catalyzed by microorganisms was studied. It was found that o-phenylenediamine, sinomenine and half- O-phenylenediamine could induce the transformation of sinomenine into a novel metabolite of the structure in the mixed culture system of Antrodiella semisupina. Sinomenine N-oxide (4) was identified by NMR and EI-MS. The first report of microbial transformation of sinomenine sinomenine N-oxide (4), for the discovery of new anti-inflammatory molecules and lead compounds provide a reference.