胎儿新生儿溶血病(hemolytic disease of the fetus and newborn,HDFN)是一组由于母婴血型不合引起的胎儿或新生儿同种免疫性溶血性疾病。该病患儿通常较其他原因引起的高胆红素血症患儿具有更早的发病年(胎)龄,更高的胆红素峰值和更长的病程周期,可严重影响胎儿、新生儿及围产期妇女的身心健康。同时,随着国内二胎政策的执行,以前较为罕见的Rh、Diego血型系统不合导致的 Hemolytic disease of the fetus and newborn (HDFN) is a group of alloimmune hemolytic diseases caused by incommunicable maternal and neonatal blood types. The patient usually has an earlier age at onset (fetal), higher bilirubin peak and longer duration of disease than other causes of hyperbilirubinemia, which can seriously affect the fetus, newborn And perinatal women’s physical and mental health. At the same time, with the implementation of the policy of the second child in China, the previously rare Rh and Diego blood group system caused by the incompatibility