四甲基吡嗪又名川芎嗪,它是枯草杆菌的代谢产物~[1].六十年代以来对其生理、生化及生物合成的研究略有报导,发现它有较明显的强心作用.它是我国近年来创制的脑血管扩张新药~[2],对治疗急性脑血管病及其后遗症、脑缺血性疾病具有显著疗效~[8].关于四甲基吡嗪的化学反应及其衍生物的报导不多,仅有以钠氨或苯基锂作为缩合 Tetramethylpyrazine, also known as ligustrazine, is a metabolite of Bacillus subtilis [1] .Since the 1960s, the study of its physiology, biochemistry and biosynthesis was slightly reported and it was found that it had obvious cardiac effects. It is our country in recent years created a new drug of cerebrovascular expansion ~ [2], for the treatment of acute cerebrovascular disease and its sequelae, cerebral ischemic disease has a significant effect ~ [8] on tetramethylpyrazine chemical reaction and its Derivatives reported little, only sodium ammonia or phenyllithium as condensation