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近年我科在用异烟肼、利福平、吡嗪酰胺或乙胺丁醇治疗肺结核同时加用氧氟沙星使痰菌阴转获得较好效果,现报道如下。 1 资料与方法 1.1 病例选择自1992年～1993年12月我科对79例住院患者按照入院顺序随机划分治疗组和对照组。治疗组41例,男28例,女13例,平均年龄44.15±5.13岁。对照组38例,男27例,女11例,平均年龄44.4±5.16岁。两组患者年龄、性别、初复治例数、治疗前痰菌阴阳例数均经卡方检验无显著差异(P>0.05)。 1.2 治疗及观察方法两组患者治疗前均检查肝功能、肾功能、血常规、尿常规、血沉、胸片、痰涂片(连续二个早晨)。治疗后25～30天复查以上各项目。治疗组采用异烟肼(INH)0.3～0.4g,利福平(RFP)0.45～0.6g,均以早晨空腹服用,吡嗪酰胺(PZA)0.75g每日2次;或乙胺丁醇(EMB)0.75g每日1次,加用氧氟沙星0.3g每日2次。对照组单用异烟肼、利福平、吡嗪酰胺或乙胺丁醇。在治疗过程中经临床观察未发现明显毒副作用。
In recent years, our department with isoniazid, rifampin, pyrazinamide or ethambutol treatment of pulmonary tuberculosis while ofloxacin plus sputum negative conversion to obtain better results are reported below. 1 Materials and Methods 1.1 Case Selection From 1992 to December 1993, 79 cases of our hospitalized patients were randomly divided into treatment group and control group according to admission sequence. Treatment group of 41 patients, 28 males and 13 females, mean age 44.15 ± 5.13 years. The control group of 38 patients, 27 males and 11 females, with an average age of 44.4 ± 5.16 years. Two groups of patients age, gender, the number of cases of initial re-treatment, the number of sputum yin and yang before treatment by chi-square test showed no significant difference (P> 0.05). 1.2 Treatment and observation of two groups of patients before treatment were examined liver function, renal function, blood, urine, ESR, chest radiograph, sputum smear (two consecutive mornings). 25 to 30 days after treatment review the above items. The patients in the treatment group were treated with 0.3 ~ 0.4g of INH and 0.45 ~ 0.6g of rifampicin (RFP) in the morning on an empty stomach, 0.75g of PZA 0.75g twice daily or ethambutol EMB) 0.75g daily 1, plus ofloxacin 0.3g 2 times a day. The control group used isoniazid, rifampin, pyrazinamide or ethambutol alone. In the course of treatment by clinical observation found no significant side effects.