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胞液型磷脂酶A2能引发关节炎,针对胞液型磷脂酶A2的抑制剂有可能成为治疗关节炎的特效药,因此引起了广泛的关注.文章对于吡咯烷类胞液型磷脂酶A2抑制剂进行了三维定量构效关系研究,利用比较分子力场分析构建了该类分子的定量构效关系,得到三维等值线图,为胞液型磷脂酶A2抑制剂的进一步改造提供了有益的启示.
Cytosolic phospholipase A2 can cause arthritis, cytosolic phospholipase A2 inhibitors may become the cure for arthritis, which has aroused widespread attention.For the pyrrolidine cytosolic phospholipase A2 inhibition Agents were used to study the quantitative structure-activity relationship. The quantitative structure-activity relationship of these molecules was constructed by comparative molecular force field analysis, and the three-dimensional contour map was obtained. This provides a useful method for the further transformation of cytosolic phospholipase A2 inhibitors Inspiration.