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目的:观察复方苦参注射液联合化疗治疗晚期结肠癌的临床疗效。方法:将本院收治的IV期结肠癌患者72例,随机分为治疗组36例和对照组36例。对照采用单纯化疗治疗,治疗组在对照组的治疗基础上加用复方苦参注射液每日静滴治疗,两组疗程均为3个月。治疗结束后,观察两组疗效并做比较。结果:治疗组36中,完全缓解7例,部分缓解15例,稳定10例,进展4例,总有效率为61.11%。对照组36中,完全缓解3例,部分缓解7例,稳定15例,进展11例,总有效率为27.28%。两组总有效率比较,治疗组明显高于对照组,差异有统计学意义(P<0.05)。两组患者在治疗过程中均有恶心呕吐、白细胞下降等不良反应发生,但治疗组的发生率及严重程度均明显低于对照组,差异有统计学意义(P<0.05)。结论:复方苦参注射液联合化疗治疗可明显提高晚期结肠癌临床疗效,降低不良反应的发生率,可显著提高患者的生活质量。
Objective: To observe the clinical curative effect of compound Kushen injection combined with chemotherapy for advanced colon cancer. Methods: 72 patients with stage IV colon cancer admitted to our hospital were randomly divided into treatment group (36 cases) and control group (36 cases). Control with chemotherapy alone, the treatment group in the control group based on the treatment with compound Kushen injection daily intravenous infusion of two courses of treatment were 3 months. After treatment, the two groups were observed and compared. Results: In treatment group 36, 7 cases were completely relieved, 15 cases partially relieved, 10 cases stabilized and 4 cases progressed. The total effective rate was 61.11%. In control group 36, complete remission in 3 cases, partial remission in 7 cases, stable in 15 cases, progression in 11 cases, the total effective rate was 27.28%. The total effective rate of the two groups, the treatment group was significantly higher than the control group, the difference was statistically significant (P <0.05). Both groups had nausea, vomiting and leukopenia during the course of treatment, but the incidence and severity of the treatment group were significantly lower than that of the control group (P <0.05). Conclusion: Compound Kushen injection combined with chemotherapy can significantly improve the clinical efficacy of advanced colon cancer, reduce the incidence of adverse reactions, can significantly improve the quality of life of patients.