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在低价钛(TiCl_4-Zn)试剂作用下,4-硝基酮发生分子内还原成环反应,生成△’-吡咯啉.在同样条件下,4-硝基-1,7-二酮则可反应得到产率较高的8-氮杂双环[3.2.1]辛烷.该化合物具有颠茄生物碱母核结构.从而本文提供了合成这类化合物的新方法.
Under the action of TiCl 4 -Zn reagent, 4-nitro ketone undergoes intramolecular reductive cyclization to form △ ’- pyrroline. Under the same conditions, 4-nitro-1,7-dione Which can be reacted to give 8-azabicyclo [3.2.1] octane with high yield. This compound has the nuclear structure of belladonna alkaloid and thus provides a new method for the synthesis of these compounds.