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目的:探讨血清组蛋白去乙酰化酶3（HDAC3）对稳定性冠心病患者经皮冠状动脉介入治疗（PCI）术后主要心血管不良事件（MACE）的预测价值。方法:选取2017年10月至2018年10月上海市第六人民医院金山分院接受PCI的80例稳定性冠心病患者作为研究对象，按照是否发生MACE分为MACE组26例和非MACE组54例，比较两组患者一般临床资料、血脂指标、HDAC3、C反应蛋白（CRP）水平的差异，采用Logistic回归分析稳定性冠心病患者PCI术后MACE的独立危险因素，应用受试者工作特征（ROC）曲线分析HDAC3对稳定性冠心病患者术后发生MACE的预测价值。结果:两组患者在性别构成、年龄、体质量指数、吸烟史、饮酒史、心力衰竭史、高血压、高脂血症、糖尿病、血管病变支数方面比较差异无统计学意义（n P>0.05）；MACE组Gensini积分高于非MACE组[（18.47 ± 3.23）分比（14.46 ± 3.62）分]，差异有统计学意义（n P0.05）；MACE组HDAC3、CRP水平高于非MACE组[（3.93 ± 0.50） mg/L比（2.92 ± 0.56） mg/L、（22.06 ± 4.56） mg/L比（17.56 ± 3.28） mg/L]，差异有统计学意义（n P<0.05）。Logistic回归分析显示，HDAC3、CRP、Gensini积分是稳定性冠心病患者PCI术后发生MACE的独立危险因素（n P<0.05）。ROC曲线分析显示，血清HDAC3、CRP、Gensini积分预测稳定性冠心病患者PCI术后发生MACE的曲线下面积（AUC）分别为0.924、0.785、0.803；血清HDAC3对稳定性冠心病患者PCI术后发生MACE的诊断效能高于CRP、Gensini积分（n Z = 2.019、2.147，n P0.05). The Gensini scores in the MACE group was significantly higher than that in the non-MACE group [(18.47 ± 3.23) vs. (14.46 ± 3.62)](n P0.05). The levels of HDAC3 and CRP in the MACE group were significantly higher than those in the non-MACE group [(3.93 ± 0.50) mg/L vs. (2.92 ± 0.56) mg/L, (22.06 ± 4.56) mg/L vs. (17.56 ± 3.28) mg/L] (n P<0.05). Logistic multivariate regression analysis showed that HDAC3, CRP and Gensini scores were independent risk factors for MACE in patients with stable coronary artery disease after PCI (n P<0.05). ROC curve analysis showed that the area under the curve (AUC) of serum HDAC3,CRP and Gensini scores predicted MACE in patient with stable coronary artery disease after PCI were 0.924, 0.785, 0.803. The diagnostic efficacy of serum HDAC3 was significantly higher than that of CRP and Gensini scores (n Z=2.019, 2.147, n P<0.05).n Conclusions:The up-regulation of serum HDAC3 expression has correlation with MACE in patients with stable coronary artery disease after PCI, which can be used as a predictor of MACE.