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针对三带模拟移动床色谱的实际模型 ,用一种融合了前馈与反馈的半解析优化计算方法对三带模拟移动床色谱过程进行了模拟 .首先 ,由非线性单柱色谱理论解析地给出一个三带模拟移动床色谱的主要操作参数即切换时间值 ,然后利用所得结果与目标量之间的偏差来校正切换时间 ,在理论指导下进行优化搜索 ,切换时间能很快达到最佳值 .将测得的系统参数引入计算 ,并将计算结果用于实际操作 ,得到了很好的分离效果
A three-analytical optimization method based on feedforward and feedback was used to simulate the three-zone simulated moving bed chromatography process for the practical model of three-zone simulated moving bed chromatography.Firstly, by nonlinear single-column chromatography theory, A three-band simulated moving bed chromatogram of the main operating parameters of the switching time value, and then use the results of the deviation between the target amount to correct the switching time, under the guidance of the theory to optimize the search, the switching time can be quickly reached the best value The measured system parameters are introduced into the calculation, and the calculation results are used for actual operation, and a good separation effect is obtained