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目的:观察依帕司他治疗糖尿病周围神经病变(DPN)的临床疗效,并与甲钴胺合用对照观察两组疗效差别。方法:选择住院DPN病人46例,均使用胰岛素控制血糖,随机分为观察组(A组)及对照组(B组)各23例,观察组使用依帕司他+甲钴胺+降糖通脉胶囊治疗,对照组使用甲钴胺+降糖通脉胶囊治疗,疗程均为12周,观察两组病例治疗前后的变化,并进行组间对照。结果:按症状改善程度,观察组治疗DPN有效率达到91.3%,对照组治疗DPN有效率达到52.2%,观察组疗效明显优于对照组(P<0.05)。观察两组神经传导速度,观察组优于对照组(P<0.05)。结论:依帕司他治疗DPN疗效确切,治疗病例未见不良反应。
Objective: To observe the clinical efficacy of epalrestat in the treatment of diabetic peripheral neuropathy (DPN), and observe the difference in curative effect between the two groups in combination with mecobalamin. Methods: Forty-six inpatients with DPN were enrolled in this study. All of them were treated with insulin to control blood glucose. They were randomly divided into observation group (group A) and control group (group B) with 23 cases each. Patients in observation group were treated with ipamustine plus mecobalamin Vein capsule treatment, the control group mecobalamin + Jiangtang Tongmai capsule treatment, the course of treatment was 12 weeks, observed two groups of patients before and after treatment changes, and the control group. Results: According to the degree of symptom improvement, the effective rate of DPN in the observation group reached 91.3% and that of the control group reached 52.2%. The observation group had better curative effect than the control group (P <0.05). The nerve conduction velocity was observed in both groups, and the observation group was better than the control group (P <0.05). Conclusion: The treatment of DPN with epalrestat is effective and no adverse reactions are observed in the treated cases.