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采用3H-TdR释放法分别检测了单纯NK细胞活性及红细胞作用下NK细胞的活性,结果显示肺癌患者外周血NK细胞活性(23.78%±6.34%)较正常对照组(41.37%±7.43%)明显降低(P<0.005),但在正常人红细胞作用下,其NK细胞毒活性为30.30%±6.56%,经配对设计t检验有显著性差异(P<0.001);在肺癌患者红细胞作用下,机体NK细胞活性无明显变化,经检验不存在显著性差异(P>0.05)。表明正常人红细胞对自身及肺癌患者的NK细胞活性均有显著的促进作用,在肿瘤免疫学及临床肿瘤的治疗方面将有积极的意义。
3H-TdR release method was used to detect the activity of NK cells alone and the activity of NK cells under red blood cells. The results showed that the activity of NK cells in peripheral blood of lung cancer patients (23.78% ± 6.34%) was lower than that of normal controls (41.37). %±7.43%) was significantly decreased (P<0.005), but under normal human erythrocytes, the NK cytotoxicity was 30.30%±6.56%. There was a significant difference by paired design t test. (P<0.001); Under the action of red blood cells in lung cancer patients, the body NK cell activity did not change significantly, and there was no significant difference (P>0.05). This shows that normal human red blood cells have a significant role in promoting NK cell activity in patients and lung cancer patients, and will have positive significance in tumor immunology and clinical tumor treatment.