论文部分内容阅读
目的研究降钙素原(PCT)在脑膜炎患者血清和脑脊液(CSF)中的水平,探讨其在脑膜炎诊断中的临床意义。方法用免疫透射比浊法测定42例脑膜炎患者(细菌性脑膜炎18例、病毒性脑膜炎24例)急性期内血清和脑脊液PCT,并与CSF的常规生化指标作相关性分析;20例神经系统非感染性疾病为对照组。结果细菌性脑膜炎患者血清和CSF中的PCT含量均显著高于病毒性脑膜炎和对照组(P<0.01);但病毒性脑膜炎患者与对照组之间的PCT水平差异无统计学意义(P>0.05)。相关性分析显示,在CSF中PCT与白细胞数(r=0.161,P>0.05)无明显相关性,但与CSF蛋白含量和血清PCT水平呈弱相关性(r=0.465和0.570,P<0.05)。结论 PCT升高是颅内细菌感染的标志之一;PCT可作为一项CSF的常规生化指标,有助于指导临床对脑膜炎的诊治。
Objective To investigate the level of procalcitonin (PCT) in serum and cerebrospinal fluid (CSF) of patients with meningitis and to explore its clinical significance in the diagnosis of meningitis. Methods The serum and cerebrospinal fluid (CSF) of 42 cases of meningitis (18 cases of bacterial meningitis and 24 cases of viral meningitis) in the acute phase were detected by immunoturbidimetry. The correlations were analyzed with routine biochemical indexes of CSF. Twenty Nervous system non-infectious diseases as control group. Results The contents of PCT in serum and CSF of patients with bacterial meningitis were significantly higher than those of viral meningitis and control (P <0.01). However, there was no significant difference in PCT between viral meningitis patients and controls P> 0.05). Correlation analysis showed that there was no significant correlation between PCT and leucocyte count (r = 0.161, P> 0.05) in CSF, but a low correlation with CSF protein content and serum PCT level (r = 0.465 and 0.570, . Conclusions PCT elevation is one of the hallmarks of intracranial bacterial infection. PCT can be used as a routine biochemical indicator of CSF to help guide the clinical diagnosis and treatment of meningitis.