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目的观察血栓心脉宁联合奥扎格雷氯化钠注射液治疗短暂脑缺血发作(TIA)的临床疗效。方法将120例TIA患者随机分为两组,对照组采用奥扎格雷氯化钠注射液静脉滴注及其他常规治疗,治疗组在此基础上加服血栓心脉宁片。观察两组治疗前后血清高敏C反应蛋白(hs-CRP)和D-二聚体的变化。结果治疗14 d时治疗组总有效率与对照组比较差异有统计学意义(P<0.05);治疗组血清hs-CRP和血浆D-二聚体水平较对照组明显降低(P<0.05)。结论血栓心脉宁片联合奥扎格雷氯化钠能有效治疗TIA,其机制与降低患者体内的hs-CRP和D-二聚体水平有关。
Objective To observe the clinical efficacy of Xixi Ning combined with ozagrel and sodium chloride injection in the treatment of transient ischemic attack (TIA). Methods One hundred and twenty patients with TIA were randomly divided into two groups. The control group was treated with intravenous infusion of ozagrel sodium chloride and other conventional treatments. The treatment group was given thrombosis Xintangning tablets on this basis. The changes of serum high-sensitivity C-reactive protein (hs-CRP) and D-dimer before and after treatment were observed. Results The total effective rate of the treatment group on the 14th day after treatment was significantly lower than that of the control group (P <0.05). The levels of serum hs-CRP and plasma D-dimer in the treatment group were significantly lower than those in the control group (P <0.05). Conclusion Thrombosis Xintinning tablets combined with ozagrel sodium chloride can effectively treat TIA, the mechanism of which is related to reducing the level of hs-CRP and D-dimer in patients.