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提高机体免疫力是预防人、畜布氏菌病重要手段之一。长期以来,国内外都是采用活菌苗免疫接种预防人、畜布氏菌病。但是活菌苗的广泛应用,暴露出其本身的诸多缺陷,如活菌均保留一定的毒性,可致敏接种者,产生与自然感染相似的血清学反应及皮肤变态反应,在防治监测工作中无法鉴别。因此,国内外许多学者都在研究非完整菌体的布氏菌组份苗(化学疫苗)预防布氏菌感染的可能性。 作者将布氏菌特异性抗原BSAg免疫豚鼠,观察BSAg的免疫效果。
Enhance immunity is to prevent human and animal brucellosis one of the important means. For a long time, the use of live vaccine vaccination at home and abroad to prevent human and animal brucellosis. However, the wide application of live vaccine shows many of its own defects, such as live bacteria are to retain some of the toxicity can be sensitized vaccinators, and natural infection with similar serological reactions and skin allergies in the prevention and control work Unrecognized. Therefore, many scholars both at home and abroad are studying the possibility of prevention of brucellosis by non-intact bacterial body vaccine (chemical vaccine). The authors immunized guinea pigs with the Brucella-specific antigen BSAg and observed the immunogenicity of BSAg.