世界各地的水、空气和土壤中都存在自生性阿米巴。过去对它们的致病性了解甚少,直至 Culbertson 证实棘阿米巴可引起小鼠和猴的脉络丛脑膜炎,才引起医学界对自生性阿米巴致病性的关注。目前已知自生性阿米巴引起的人脑膜脑炎有两类:由纳格勒阿米巴引起的原发性阿米巴脑膜脑炎 There are autogenic amoebiasis in water, air and soil around the world. In the past, little was known about their pathogenicity until Culbertson confirmed that Acanthamoeba could cause choriomeningitis in mice and monkeys, causing the medical community to pay more attention to the pathogenicity of spontaneous amoeba. There are two types of human meningoencephalitis that are known to cause autoimmune amebiasis: primary amoebic meningoencephalitis caused by Nagler amoebic