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〔目的〕研究江苏上消化道癌高发区淮安市、低发区邳州市幽门螺旋杆菌(Hp)感染与胃癌发生的关系。〔方法〕用酶联免疫法及乳胶凝集法检测79例胃癌、77例食管癌、156名患者亲属和100名一般居民对照者血浆中Hp抗体。〔结果〕低发区胃癌患者组Hp感染率(66 67%)显著高于高发区(38 64 %) ,两地区其他组之间Hp感染率无显著差异。低发区Hp感染者患胃癌的危险性显著升高(OR3 61 ,95%CI1 01～12 94) ,高发区Hp感染与胃癌发生之间无显著关联。〔结论〕Hp感染是低发区邳州市胃癌发生的危险因素之一 ,但不是淮安市胃癌高发的原因。
[Objective] To investigate the relationship between Helicobacter pylori (Hp) infection and occurrence of gastric cancer in Huai’an City, a low-risk area, and a high incidence area of upper gastrointestinal cancer in Jiangsu Province. [Methods] Hp antibodies in plasma of 79 cases of gastric cancer, 77 cases of esophageal cancer, 156 patients’ relatives and 100 general controls were detected by enzyme-linked immunosorbent assay and latex agglutination assay. 〔Results〕 The Hp infection rate was significantly higher in the low-onset gastric cancer group (66 67%) than in the high-risk area (38 64%). There was no significant difference in Hp infection rate between the other two groups. Hp-infected individuals in low-risk areas had a significantly higher risk of developing gastric cancer (OR3 61, 95% CI1 01 to 12 94). There was no significant association between Hp infection in high-risk areas and the occurrence of gastric cancer. [Conclusion] Hp infection is one of the risk factors for gastric cancer in the low-incidence area of Ganzhou City, but it is not the cause of high incidence of gastric cancer in Huai’an City.