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氯化十六烷铵基吡啶(cetylpyridinium chloride,以下简称CPC)系季胺化合物,目前有它的几种商品漱口剂出售。以往一些研究都提示CPC可减少牙菌斑的集聚,但对龈炎的效果则不肯定,且它对人牙菌斑的生化及微生物学方面的影响几乎未被研究,有鉴及此作者在这方面进行了探讨。从医院口矫或牙周病20～49岁的病人中选40名为实验对象,另40名同年龄、性别及临床情况大致相同的患者作对照。这些病人均排除了妊娠、虚弱病及6周内曾用过抗菌素、激素治疗,而且口内至少保留有20个牙齿,这些牙齿经牙菌斑显示剂显示后应至少有10个牙围绕其颈缘能见到连续的菌斑线
Cetylpyridinium chloride (hereinafter referred to as CPC) is a quaternary amine compound and currently has several of its commercial mouthwashes for sale. In the past, some studies suggested that CPC could reduce the aggregation of dental plaque, but its effect on gingivitis was not certain. Its biochemical and microbiological effects on human plaque have hardly been studied. This aspect is discussed. Forty patients selected from hospital Orthodontics or periodontal diseases aged 20 to 49 years were selected as experimental subjects and another 40 patients with the same age, gender and clinical status were compared. These patients were ruled out of pregnancy, weakness and antibiotics have been used within 6 weeks, hormone therapy, and the mouth to retain at least 20 teeth, these teeth through the plaque display agent should have at least 10 teeth around the edge of the neck Can see the continuous plaque line