目前,关于细胞内氯离子通道蛋白(chloride intracellular channel,CLIC)具体功能和调控机制研究较少,猜测可能是细胞器和细胞核的跨膜蛋白参与调节氯离子浓度。CLICs已发现有6个亚类,其中研究最多的是CLIC1。CLIC1在细胞内有多种形态存在:可溶性单体蛋白、可溶性二聚体蛋白和寡聚体膜结合蛋白[1-2]。近年来研究发现CLIC1与肿瘤的发生和恶性转化有密切关系。本文对 At present, there are few studies on the specific function and regulation mechanism of chloride intracellular channel (CLIC) in cells, and it is speculated that the transmembrane proteins of organelles and nuclei may be involved in the regulation of chloride ion concentration. CLICs have been found in six sub-categories, of which the most studied is CLIC1. CLIC1 is present in many forms within the cell: soluble monomeric protein, soluble dimeric protein and oligomeric membrane-bound protein [1-2]. In recent years, the study found that CLIC1 and tumor occurrence and malignant transformation are closely related. This article right