为了探讨脆性糖尿病(brittle diabetes)的病程经过,作者对25例病人进行12年的随访。随访内容包括12年中酮症酸中毒或严重低血糖发作的次数,1988～1990年间糖尿病控制和并发症等情况,并回顾分析导致脆性糖尿病的因素。研究对象分为酮症酸中毒型脆性糖尿病组11例(酮症酸中毒组),为1977～1979年因糖尿病酮症酸中毒入院三次或三次以上的病人;低血糖型脆性糖尿病组14 In order to explore the course of the disease, brittle diabetes was followed up for 12 years in 25 patients. The follow-up included the incidence of ketoacidosis or severe hypoglycemia in 12 years, diabetes control and complications between 1988 and 1990, and the factors that led to fragile diabetes were reviewed. The subjects were divided into ketoacidosis type brittle diabetic group 11 cases (ketoacidosis group), from 1977 to 1979 due to diabetic ketoacidosis hospitalized three times or more patients; hypoglycemic type of brittle diabetes group 14