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目的:通过接种不同剂量的乙肝疫苗和乙肝免疫球蛋白,观察免疫效果。方法:将分娩孕妇随机分为阴性组和阳性组,其中阴性组随机分为两组,新生儿分别接种5ug乙肝疫苗联合100IU乙肝免球蛋白和5μg乙肝疫苗。阳性组新生儿接种均接种5ug乙肝疫苗和100IU乙肝免疫球蛋白。观察阳性组分娩孕妇所生的新生儿接种疫苗后阻断效果,同时比较阴性组不同疫苗接种方式的免疫效果。结果:阴性组新生儿两组接种后比较:接种5ug乙肝疫苗联合100IU乙肝免球蛋白抗-HBs产生率稍高于接种5μg乙肝疫苗新生儿,但经过统计学分析差异无统计学意义,P>0.05。阳性组接种22例中有2例未达到阻断效果。结论:HbsAg阴性母亲新生儿,仍可推行5ug乙肝疫苗联合100IU乙肝免球蛋白接种方法;而对HbsAg阳性母亲新生儿5ug乙肝疫苗和100IU乙肝免疫球蛋白联合接种方法也可以明显降低乙肝的感染率,可达到一定的阻断效果。
Objective: To observe the immune effect by inoculating different doses of hepatitis B vaccine and hepatitis B immunoglobulin. Methods: The pregnant women were divided into negative group and positive group randomly. The negative group were randomly divided into two groups. The neonates were inoculated with 5ug hepatitis B vaccine combined with 100IU hepatitis B immunoglobulin and 5μg hepatitis B vaccine respectively. Positive group of newborns were inoculated with 5ug hepatitis B vaccine and 100IU hepatitis B immunoglobulin. Observe the positive components of the delivery of pregnant women born neonates after vaccination block effect, while comparing the negative group of different immunization vaccination effect. Results: Compared with the newborns in the negative group, the incidence of anti-HBs inoculated with 5ug hepatitis B vaccine and 100IU hepatitis B immunoglobulin was slightly higher than that in the newborns vaccinated with 5μg hepatitis B vaccine, but there was no significant difference after statistical analysis (P> 0.05. Two of 22 patients in the positive group did not reach the blocking effect. Conclusions: Inoculation of 5ug hepatitis B vaccine and 100IU hepatitis B immunoglobulin can still be carried out in neonates with HbsAg-negative mothers. However, inoculation of 5ug hepatitis B vaccine and 100IU hepatitis B immunoglobulin in neonates with HbsAg positive mothers can significantly reduce the infection rate of hepatitis B , Can achieve a certain blocking effect.