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本实验以心室颤动阈(VFT)作为心室易颤性的指标,观察胆碱类物质氨甲酰胆碱对大鼠缺血心室 VFT 的影响及其与心肌 cAMP 和 cGMP 水平的关系。实验结果表明,氨甲酰胆碱可提高正常心脏和急性局部缺血心脏的 VFT,提高缺血和未缺血心肌的 cGMP 水平,但明显降低缺血心肌 cAMP 水平,使缺血和未缺血心肌的 cAMP/cGMP 比值显著降低,其作用与肾上腺素正好相反。实验结果还表明,急性局部缺血心脏的 VFT 与缺血心肌 cAMP/cGMP 比值之间有密切的负相关关系,相关系数 r=-0.905(n=22,P<0.001)。上述结果提示缺血心肌 cAMP/cGMP 比值的提高可能是急性心肌梗塞早期发生心室纤维性颤动的重要因素。
In this study, ventricular fibrillation threshold (VFT) was used as an index of ventricular fibrillation to observe the effect of carbachol on VFT of ischemic ventricular in rats and its relationship with myocardial cAMP and cGMP levels. The experimental results show that carbachol can improve the VFT of normal and acute ischemic heart, increase the level of cGMP in ischemic and non-ischemic myocardium, but significantly reduce the level of cAMP in ischemic myocardium so that ischemia and no ischemia Myocardial cAMP / cGMP ratio was significantly reduced, its role and epinephrine exactly the opposite. The experimental results also showed that there was a close negative correlation between VFT of acute ischemic heart and cAMP / cGMP ratio of ischemic myocardium, the correlation coefficient was -0.905 (n = 22, P <0.001). The above results suggest that the increase of cAMP / cGMP ratio in ischemic myocardium may be an important factor in the early occurrence of ventricular fibrillation in acute myocardial infarction.