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嗜巨噬细胞型HIV-1株在HIV-1传染后开始阶段形成病毒血症的过程中起到非常重要作用,这种选择在病毒侵入人体并被载运到淋巴组织.目前至少有三种β类趋化因子受体在HIV-1病毒侵入中起到辅助受体的作用.CXCR-4是HIV-1入侵T细胞并引起合胞体诱导(SI)的生物学行为.CCRS和并不十分常见的CCR3或CCR2b参与HIV-1进入嗜巨噬细胞型并引起嗜巨噬细胞型生物学改变.为了研究皮肤移植块物感染HIV-1,作者在体外用培养的鼠的皮肤、鼠的半耳和人的皮片过程中,DCs快速从皮肤的移植块中迁移,然后利用这一系列模型开展了一系列研究(研究HIV-1感染早期发生的细胞学机制).用人体皮肤移植块作为皮肤或粘膜HIV病毒感染选择性的模型,用嗜巨噬细胞型HIV-1病毒感染擦伤的表皮.皮肤感染后用
The macrophage-like HIV-1 strain plays a very important role in the formation of viremia at the beginning of the HIV-1 infection, when the virus invades the human body and is carried into the lymphoid tissue. At least three β Chemokine receptors play a role as co-receptors in HIV-1 viral invasion. CXCR-4 is a biological activity that HIV-1 invades T cells and causes syncytia induction (SI) .CCRS is not very common CCR3 or CCR2b is involved in HIV-1 entry into macrophage-type and causes phagocytic-type biological changes.In order to study the skin graft mass infected with HIV-1, the authors in vitro cultured mouse skin, DCs rapidly migrate from the skin graft during human skinning, and then a series of studies have been conducted using this series of models (to study the cellular mechanisms that occur early in HIV-1 infection.) Human skin graft blocks are used as the skin or A selective model of mucosal HIV infection infects the scratched epidermis with a phagocytic HIV-1 virus.