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目的探讨环磷酰胺冲击联合激素治疗难治性肾病综合征的疗效及其临床分析。方法2011年01月至2011年11月期间,我院诊治的40例难治性肾病综合征患者,随机将其分为对照组(常规激素治疗)和观察组(环磷酰胺冲击联合激素治疗),每组各20例,对两组临床疗效、不良反应进行观察和比较。结果 20例观察组患者中,完全缓解的有13例,部分缓解的有6例,未缓解的有1例;20例对照组患者中,完全缓解的有8例,部分缓解的有9例,未缓解的有3例。与对照组的总缓解率相比(85.0%),观察组的总缓解率明显增高(95.0%),P<0.05。观察组患者中,1例患者出现胃肠道反应,经过对症治疗后,症状缓解;对照组患者中,2例患者出现呼吸道感染,2例患者出现胃肠道反应,经过对症治疗后,症状缓解。与对照组相比(5.0%),观察组的不良反应发生率明显降低(20.0%),P<0.05。结论对于难治性肾病综合征的治疗,环磷酰胺冲击联合激素治疗显著提高临床疗效,并且不良反应少。
Objective To investigate the curative effect and clinical analysis of cyclophosphamide combined with hormonal therapy on refractory nephrotic syndrome. Methods From January 2011 to November 2011, 40 patients with refractory nephrotic syndrome treated in our hospital were randomly divided into control group (conventional hormone therapy) and observation group (cyclophosphamide combined with hormone therapy) , 20 cases in each group, the clinical efficacy and adverse reactions in both groups were observed and compared. Results Among the 20 patients in the observation group, 13 were completely relieved, 6 were partially relieved, and 1 was not relieved. Among 20 patients in the control group, 8 were completely relieved, 9 were partially relieved, 3 cases did not relieve. Compared with the overall response rate of the control group (85.0%), the overall response rate of the observation group was significantly higher (95.0%), P <0.05. In the observation group, one patient showed gastrointestinal reaction and symptomatic treatment after symptomatic treatment. In the control group, two patients had respiratory infection and two patients had gastrointestinal reaction. After symptomatic treatment, the symptoms were relieved . Compared with the control group (5.0%), the incidence of adverse reactions in the observation group was significantly lower (20.0%), P <0.05. Conclusion For the treatment of refractory nephrotic syndrome, cyclophosphamide combined with hormone therapy significantly improve the clinical efficacy, and less adverse reactions.