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目的研究乳腺原发性非霍奇金淋巴瘤的临床病理特点与预后。方法对中国医学科学院肿瘤医院1999-2008年23例乳腺原发性非霍奇金淋巴瘤的临床资料进行分析,复习病史、治疗经过和随访资料。结果弥漫大B细胞淋巴瘤11例,黏膜相关边缘带B细胞淋巴瘤伴大细胞转化5例,小淋巴细胞淋巴瘤5例,自然杀伤细胞(NK)/T细胞淋巴瘤1例,Burkitt淋巴瘤1例。肿物切除20例,乳腺改良根治手术3例。9例手术后化疗,6例手术后化疗和放疗,1例化疗缓解后造血干细胞移植。21例随访3～62个月,17例存活,4例死亡,2例失访。12例有复发和进展。结论乳腺原发性非霍奇金淋巴瘤最常见的组织学类型是弥漫大B细胞淋巴瘤。肿瘤切除术加放疗和(或)化疗是主要治疗方法,预后差,易于复发。
Objective To study the clinicopathological features and prognosis of primary non-Hodgkin lymphoma in breast. Methods The clinical data of 23 cases of primary non-Hodgkin’s lymphoma of the breast from 1999 to 2008 in Cancer Hospital of Chinese Academy of Medical Sciences were analyzed and the history, treatment and follow-up data were reviewed. Results In 11 cases of diffuse large B-cell lymphoma, mucosal associated borderline B-cell lymphoma with large cell transformation in 5 cases, 5 cases of small lymphocytic lymphoma, 1 case of natural killer (NK) / T cell lymphoma, 1 case of Burkitt’s lymphoma 1 case. Tumescent resection in 20 cases, modified radical mastectomy in 3 cases. 9 cases of postoperative chemotherapy, 6 cases of postoperative chemotherapy and radiotherapy, and 1 case of chemotherapy after hematopoietic stem cell transplantation. Twenty-one patients were followed up for 3 to 62 months, 17 survived, 4 died and 2 lost their follow-up. Twelve cases had recurrence and progression. Conclusions The most common histologic type of primary non-Hodgkin’s lymphoma is diffuse large B-cell lymphoma. Tumor resection plus radiotherapy and / or chemotherapy is the main treatment, the prognosis is poor, easy to relapse.