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目的探讨血清前白蛋白检测对早产儿败血症早期诊断的临床意义。方法早产儿47例,其中早产儿败血症(疾病组)21例,血培养阳性;早产儿生活能力低下(对照组)26例;两组患儿入、出院时检测血清前白蛋白及C-反应蛋白(CRP)。结果疾病组早产儿入、出院时血清前白蛋白为[(95.23±10.46)mg/Lvs.(142.23±10.38)mg/L]、CRP为[(32.18±11.27)mg/Lvs.(3.05±2.09)mg/L],差异有统计学意义(P<0.01);对照组早产儿入、出院时血清前白蛋白为[(123.67±10.87)mg/Lvs.(144.14±10.81)mg/L],CRP为[(2.02±0.27)mg/Lvs.(1.98±0.19)mg/L],差异无统计学意义(P>0.05)。疾病组早产儿入院时血清前白蛋白、CRP与对照组比较,差异有统计学意义(P<0.01)。结论血清前白蛋白及CRP变化与感染高度相关,血清前白蛋白是检测早期早产儿感染的一项敏感指标。
Objective To investigate the clinical significance of serum prealbumin in the early diagnosis of sepsis in premature infants. Methods Forty-seven premature infants were preterm infants with septicemia (disease group), 21 with positive blood culture, and 26 with poor viability in preterm infants (control group). Pre-serum albumin and C- Protein (CRP). Results The prealbumin level in preterm infants in the disease group was (95.23 ± 10.46) mg / L vs (142.23 ± 10.38) mg / L and the CRP was (32.18 ± 11.27) mg / L vs 3.05 ± 2.09 ) (mg / L), the difference was statistically significant (P <0.01). The prealbumin level in the control group was (123.67 ± 10.87) mg / L vs 144.14 ± 10.81 mg / L The CRP was (2.02 ± 0.27) mg / L vs (1.98 ± 0.19) mg / L, the difference was not statistically significant (P> 0.05). Serum prealbumin and CRP levels in preterm infants in the disease group were significantly different from those in the control group (P <0.01). Conclusions The changes of prealbumin and CRP are highly correlated with the infection. Prealbumin is a sensitive indicator of early premature infant infection.