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作者报道甲硝唑有维持缓解溃疡性结肠炎的作用。 35例缓解1～11个月的溃疡性结肠炎患者,随机双盲接受甲硝唑和柳氮磺胺吡啶(S)维持治疗。20例口服甲硝唑0.15 g,一日4次和15例服S 0.5 g,一日4次,持续12个月或直至复发。结果发现甲硝唑维持缓解9例,S组则为3例,p<0.05。12个月后,甲硝唑治疗者复发率明显低于S组(p<0.05)。对急性发作的病人,每日服S 2～3 g,持续1～3个月,待病情缓解后进行开放交叉用药,甲硝唑治疗者3例维持缓解12个月,6
The authors report that metronidazole has the effect of relieving ulcerative colitis. Thirty-five patients with ulcerative colitis who had been relieved for 1 to 11 months were randomized to double-blind treatment with metronidazole and sulfasalazine (S). 20 cases of oral metronidazole 0.15 g, 4 times a day and 15 cases serving S 0.5 g, 4 times a day for 12 months or until relapse. The results showed that metronidazole maintained remission in 9 cases, S group was 3 cases, p <0.05.12 months later, the recurrence rate of metronidazole treatment group was significantly lower than the S group (p <0.05). Acute attack patients, daily serving S2 ~ 3g, continued for 1 to 3 months, until the disease was relieved open cross medication, metronidazole treatment in 3 patients to maintain remission for 12 months, 6