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目的了解待产孕妇阴道分泌物中甲氧西林耐药金黄色葡萄球菌(MRSA)和甲氧西林敏感金黄色葡萄球菌(MSSA)的耐药情况。方法对深圳龙华区入院待产的孕妇阴道分离出的33株MRSA和118株MSSA进行药敏试验。结果 MRSA和MSSA对克林霉素、红霉素、替考拉宁和青霉素的耐药率均较高,而MRSA和MSSA对利奈唑胺和利福平的敏感率均在90%以上。MRSA菌株的多重耐药率高达84.85%,而MSSA也达到了61.02%,MRSA多重耐药风险是MSSA的3.6倍。结论龙华区孕妇阴道定植的金黄色葡萄球菌尤其是MRSA具有高多重耐药危险性,其耐药范围广、耐药率高,临床上应合理用药。
Objective To investigate the drug resistance of methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA) in the vaginal secretions of expectant mothers. Methods 33 strains of MRSA and 118 strains of MSSA isolated from vagina of pregnant women admitted to Longhua District of Shenzhen were tested for susceptibility. Results The rates of resistance to clindamycin, erythromycin, teicoplanin and penicillin were higher in MRSA and MSSA, while the sensitivity of MRSA and MSSA to linezolid and rifampicin was over 90%. The multi-drug resistance rate of MRSA strains was as high as 84.85%, while that of MSSA reached 61.02%. The risk of MRSA multi-drug resistance was 3.6 times that of MSSA. Conclusion Staphylococcus aureus vaginally colonized by pregnant women in Longhua district, especially MRSA, is at high risk of multiple drug resistance. Its drug resistance range is wide and its drug resistance rate is high. Therefore, it should be used clinically rationally.