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本文从RSV特异的IgE抗体(RSV-IgE),嗜硷粒细胞和组织胺三方面,探讨了RSV毛细支气管炎喘鸣的发病机理。实验发现,RSV毛细支气管炎患儿的鼻咽分泌液(NPS)中RSV-IgE和组织胺显著升高,外周血嗜硷粒细胞绝对数升高,对 RSV抗原敏感性高,脱颗粒阳性率高。初步证实 IgE介导Ⅰ型变态反应参与了 RSV毛细支气管炎的发病。同时发现,RSV-IgE在患儿体内持续存在,这可能是 RSV毛细支气管炎喘鸣患儿在病后数年中反复出现喘鸣的原因之一。
In this paper, the pathogenesis of RSV bronchiolitis is explored from RSV-specific IgE antibody (RSV-IgE), basophil and histamine. The results showed that the RSV-IgE and histamine in nasopharyngeal fluid (NPS) of children with RSV bronchiolitis were significantly increased, the absolute number of peripheral blood alkaline cells increased, the sensitivity to RSV antigen was high, the positive rate of degranulation high. Preliminary confirmed IgE-mediated type I allergic reactions involved in the pathogenesis of RSV bronchiolitis. Also found that, RSV-IgE persist in children, which may be RSV bronchiolitis in children with wheezing recurrent wheezing in the years after the cause of one of the reasons.