THE ROLE OF LOW FREQUENCY (ACOUSTIC) PHONONS IN DETERMINING THE PREMELTING AND MELTING BEHAVIOUS OF

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THIS paper discusses the role of low frequency (acoustic) pho-nons in determining the premelting and melting behavior of DNA.It is shown that acoustic phonons play an important role in de-termining the magnitude of energy fluctuations along the DNAmolecule--this reflects heterogeneity in DNA flexibility as-sociated with different stacking energies that stabilize variouscombinations of nucleotide sequences in its structure.Regionsof DNA having greater flexibility undergo larger energy fluctua-tions.As a result,these regions have higher probability thatconformational changes occur and that (once occurring) such re-gions undergo still larger energy fluctuations.This can in-crease the rates of such kinetic processes as drug intercalation,DNA breathing and protein-DNA recognition.Acoustic phonons play an important role in determining thestructural and energeticaspects of DNA premelting and meltingand lead to an understanding of the cooperativity in DNA melting.We discuss these questions here. THIS paper discusses the role of low frequency (acoustic) pho-nons in determining the premelting and melting behavior of DNA. It is shown that acoustic phonons play an important role in de-termining the magnitude of energy fluctuations along the DNA molecule. heterogeneity in DNA flexibility as-sociated with different stacking energies that stabilize variouscombinations of nucleotide sequences in its structure. Regulations of DNA having greaterbility readily larger energy fluctuations- .As a result, these regions have higher probability thatconformational changes occur and that (once occurring ) such re-gagesize here still can increase the energy fluctuations. this can in-crease the rates of such kinetic processes as drug intercalation, DNA breathing and protein-DNA recognition. Acoustic phonons play an important role in determining the structure and energetic aspects of DNA premelting and meltingand lead to an understanding of the cooperativity in DNA melting.We discuss these questions her e.
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