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研究卡巴胆碱对MODS病人肠功能障碍的治疗作用。通过前瞻性、多中心、随机对照临床试验将入选病人随机分为两组,分别于入组0 h、用药后24,48,72 h、第7天或死亡前取血行血浆内毒素、血D-乳酸的测定。临床动态监测肠鸣音恢复情况、腹胀、排便、肠管积气、积液情况,以在上述各时点评定两组患者胃肠功能评分。卡巴胆碱治疗组与莫沙必利治疗组相比,血浆D-乳酸、内毒素及胃肠功能评分均有显著变化(P<0.05)。卡巴胆碱能有效改善MODS病人肠道功能、减轻其炎症反应。
To study the therapeutic effect of carbachol on intestinal dysfunction in MODS patients. The prospective, multicenter and randomized clinical trial randomized the patients into two groups. Blood samples were collected at 0 h, 24 h, 48 h, 72 h, and 7 d after dosing, or plasma levels of endotoxin, blood D Determination of lactic acid. Clinical dynamic monitoring of bowel sounds recovery, abdominal distension, defecation, intestinal gas accumulation, effusion, in order to assess the two groups at each time point gastrointestinal function score. The levels of plasma D-lactate, endotoxin and gastrointestinal function in carbachol treatment group were significantly different from those in mosapride treatment group (P <0.05). Carbachol can effectively improve the intestinal function of patients with MODS and reduce their inflammatory response.