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实验在清醒禁食家兔通过记录小肠平滑肌电活动的变化观察了银杏内酯A(Ginkgolide A)时内毒素所致小肠运动功能损害的保护作用。实验动物随机分成对照组、内毒素致病组和银杏内酯预处理组。分别记录用药前后和组别之间小肠移行性综合肌电(IMC)周期、各时相时程以及慢波和快波变化情况。发现内毒素30μg/kg静脉注射可引起小肠肌电活动明显抑制和紊乱,IMC中断并诱发出间断性不规则高峰电活动;银杏内酯A 5mg/kg的预处理可显著压抑(P<0.01,n=12)内毒素所致的这一毒性反应,可使IMC周期恢复提前,IMC的各时相时程以及慢波频率和幅度接近于对照水平而不规则高峰电活动时间缩短。结果表明,银杏内酯可通过强烈抑制内毒素介导的小肠肌电紊乱调整平滑肌运动功能。
The experiment observed the protective effect of endotoxin-induced small intestine locomotor impairment in Ginkgolide A by observing the change of the activity of small intestine smooth muscle in awake fasted rabbits. Experimental animals were randomly divided into control group, endotoxin-induced group and ginkgo lactone pretreatment group. The transitional integrated electromyography (IMC) cycle, the time course of each phase, and the changes of slow wave and fast wave in the small intestine before and after treatment were recorded. It was found that endotoxin 30μg/kg intravenous injection can cause significant inhibition and disturbance of myoelectric activity of the small intestine, and IMC interruption and induce intermittent intermittent peak electrical activity; preconditioning of ginkgolide A 5mg/kg can be significantly suppressed (P<0.01, n=12) This toxicity caused by endotoxin can lead to early recovery of IMC cycle. The time course of IMC and the frequency and amplitude of slow wave are close to the control level and the irregular peak activity time is shortened. The results showed that ginkgolide can regulate smooth muscle motor function by strongly inhibiting endotoxin-mediated intestinal myoelectric disturbance.