单克隆抗体(Mabs)具有特异性高和适于大量制备的特点,它为免疫学诊断提供了进一步标准化的前景.然而,Mab有一个重要问题就是存在着高度的测定方法特异性(assay-specific),即在一种检测中某Mab有极高效价,而在另一测定中仅有中度、甚至阴性结果.这种现象使那些欲将Mabs商品化的研究者感到提心吊胆.过去 Monoclonal antibodies (Mabs), with their high specificity and suitability for mass preparation, provide the prospect of further standardization in immunological diagnosis However, there is a significant problem with Mabs in that there is a high degree of assay-specific ), That is, one Mab in one test had an extremely high titer and only moderate or even negative results in the other test. This phenomenon made the researchers who commercialized Mabs feel nervous.