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目的探讨胃癌患者血浆血管内皮生长因子(VEGF)和白细胞介素-6(IL-6)水平的变化及其与胃癌临床病理学特征的关系。方法应用酶联免疫吸附法测定68例胃癌患者血浆VEGF及IL-6水平,结合临床病理学资料进行分析。结果胃癌患者血浆VEGF和IL-6水平均显著高于对照组(P<0.01),VEGF、IL-6水平与肿瘤大小、血管侵犯、淋巴结受累及肝脏转移密切相关(P<0.05);随着临床病理分期的升高,VEGF及IL-6水平亦明显升高(P<0.05)。血浆VEGF及IL-6水平与肿瘤组织学类型及患者的性别、年龄等因素无关(P>0.05),血浆VEGF、IL-6之间成正相关(P<0.05)。结论血浆VEGF、IL-6水平与胃癌浸润、转移等有关。联合检测血浆VEGF、IL-6对胃癌的诊断、疗效判断等有一定的价值。
Objective To investigate the changes of plasma vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) levels in patients with gastric cancer and their relationship with clinicopathological features. Methods The levels of plasma VEGF and IL-6 in 68 patients with gastric cancer were determined by enzyme-linked immunosorbent assay (ELISA) and analyzed with clinicopathological data. Results The levels of plasma VEGF and IL-6 in patients with gastric cancer were significantly higher than those in the control group (P <0.01). The levels of VEGF and IL-6 were closely related to tumor size, vascular invasion, lymph node involvement and liver metastasis (P <0.05) Clinicopathological staging increased, VEGF and IL-6 levels also significantly increased (P <0.05). Plasma VEGF and IL-6 levels had no correlation with tumor histological type and gender, age and other factors (P> 0.05). There was a positive correlation between plasma VEGF and IL-6 (P <0.05). Conclusion The plasma levels of VEGF and IL-6 are related to the infiltration and metastasis of gastric cancer. Joint detection of plasma VEGF, IL-6 on the diagnosis of gastric cancer, the efficacy of judgment has a certain value.