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药物口服后主要在小肠上端吸收,因此,药物在胃内滞留时间会显著地影响药物的吸收速率.这是因为,滞留时间决定着药物从摄入至进小肠的时间,因此,促进胃排空的一些因素可以提高药物的吸收速率.胃中食物对胃排空时间有显著性影响已是众所周知,但是体位影响胃排空时间以及由此而影响药物吸收速率却未能为众人所熟知.1978年曾有报道,同样的病人服用扑热息痛后,处于左侧卧的状态与非卧床状态相比较,药物吸收显著减慢.
Since the drug is mainly absorbed in the upper part of the small intestine after oral administration, the residence time of the drug in the stomach can significantly affect the rate of absorption of the drug because the residence time determines the time from the intake of the drug to enter the small intestine and therefore promotes gastric emptying Is known to increase gastric emptying time, but it is not well known that body position affects the time of gastric emptying and therefore the rate of drug absorption .1978 It has been reported in the past year that the same patient who took paracetamol experienced a significant slowdown in drug absorption when compared to the ambulatory condition in the left flank.