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脑膜瘤虽为良性肿瘤,但部分肿瘤可侵袭周围正常解剖结构,且术后易复发。肿瘤的生长和侵袭需要丰富的血管为其提供充足的氧和营养,脑膜瘤又为富含血管的实体肿瘤,其血管新生与促血管生成因子、抗血管生成因子之间的失衡有关。因此,对脑膜瘤血管新生分子机制的研究,有助于认识脑膜瘤血管新生的内在机理及脑膜瘤侵袭性生物学行为的特点,为脑膜瘤抗血管治疗和术后辅助分子靶向治疗以降低复发率提供理论依据。
Although meningioma is a benign tumor, some tumors can invade the normal surrounding anatomical structures, and recurrence is easy after the operation. Tumor growth and invasion require abundant blood vessels to provide adequate oxygen and nutrition, and meningiomas are also solid tumors rich in blood vessels, angiogenesis and angiogenesis factors, anti-angiogenic factors imbalance between. Therefore, the study on the molecular mechanism of meningioma angiogenesis helps to understand the intrinsic mechanism of meningioma angiogenesis and invasive biological behavior of meningioma, for meningioma anti-vascular therapy and postoperative adjuvant molecular targeted therapy to reduce The recurrence rate provides a theoretical basis.