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采用小剂量尿激酶引起轻微游离纤溶活性,克服尿激酶原的延迟相,可以大大提高溶栓成功率。本文探讨急性心肌梗塞(AMI)病例使用小剂量尿激酶预先激活尿激酶原进行治疗的效果。方法对象为 AMI 发作<4小时,至少二个相邻导程 S-T 段抬高≥2mm 且无近期出血、手术、妊娠等反指征的75岁以下病例。试验按照非盲、非随机的方式进行。列入试验后立即推注5000IU 肝素,然后滴注1250IU。随即开始溶栓治疗,250000IU 尿激酶
The use of small doses of urokinase cause slight fibrinolytic activity, to overcome the delayed phase of prourokinase, can greatly improve the success rate of thrombolysis. This article investigates the efficacy of primed pro-urokinase in patients with acute myocardial infarction (AMI) using low-dose urokinase. METHODS: Subjects under 75 years of age who had an AMI episode <4 hours and at least two adjacent leads with an S-T elevation ≥2 mm and no recent evidence of haemorrhage, surgery, or pregnancy were included. The tests were conducted in a non-blind, non-random manner. Immediately after enrollment, 5000 IU heparin was bolted and then 1250 IU was instilled. Thrombolysis began immediately, 250000IU urokinase