胃肠黏膜的慢性损伤是胃肠道肿瘤发生的病理基础,因此快速修复受损的上皮细胞对预防肿瘤的发生具有非常重要的意义。三叶因子家族作为胃肠道腔内因子,在胃肠道的保护和修复中发挥着重要作用,近年来大量的研究表明TFF1与胃癌的关系密切,是重要的抑癌基因。就TFF1的表达、功能及与胃癌关系做一综述。 Chronic injury of gastrointestinal mucosa is the pathological basis of gastrointestinal cancer, so the rapid repair of damaged epithelial cells is very important to prevent the occurrence of tumors. As a luminal factor in the gastrointestinal tract, the trefoil factor family plays an important role in the protection and repair of the gastrointestinal tract. In recent years, a large number of studies have shown that TFF1 is closely related to gastric cancer and is an important tumor suppressor gene. TFF1 expression, function and relationship with gastric cancer are reviewed.